Pills on a US dollar bill

“Megafinanziamenti” per la Ricerca sui Farmaci

SEATTLE – Sebbene faccia notizia la pratica di prezzi speculativi da parte di alcune aziende farmaceutiche, un aspetto inquietante della vicenda rimane sottovalutata. Gli aumenti esorbitanti dei prezzi dei farmaci esistenti, compresi quelli generici, non sono motivati solo dalla mera speculazione, ma da un profondo scetticismo sulla fattibilità economica di sviluppo di nuovi farmaci. Tale scetticismo è giustificato.

I modelli tradizionali per il finanziamento dello sviluppo di farmaci sono incerti. Negli Stati Uniti e in molti altri paesi sviluppati, il costo medio per portare un nuovo farmaco sul mercato è salito alle stelle, anche se sono scaduti i brevetti su alcuni dei farmaci più redditizi del settore. Il capitale di rischio si è ritirato dalle aziende bio-scientifiche di nuova costituzione, e per ogni dollaro speso in ricerca e sviluppo le grandi aziende farmaceutiche hanno visto un minor numero di farmaci raggiungere il mercato.

Infatti, in media, solo uno ogni 10.000 composti identificati come potenzialmente utili nella fase iniziale della ricerca alla fine riceverà l’approvazione da parte dei regolatori. Il processo di approvazione può richiedere fino a 15 anni ed eccede per eccesso di cautela. Anche per i farmaci che vengono sottoposti a test clinici sull’uomo, solo uno su cinque supererà tale ultimo ostacolo.

To continue reading, please log in or enter your email address.

Registration is quick and easy and requires only your email address. If you already have an account with us, please log in. Or subscribe now for unlimited access.

required

Log in

http://prosyn.org/JUTV95i/it;
  1. Chris J Ratcliffe/Getty Images

    The Brexit Surrender

    European Union leaders meeting in Brussels have given the go-ahead to talks with Britain on post-Brexit trade relations. But, as European Council President Donald Tusk has said, the most difficult challenge – forging a workable deal that secures broad political support on both sides – still lies ahead.

  2. The Great US Tax Debate

    ROBERT J. BARRO vs. JASON FURMAN & LAWRENCE H. SUMMERS on the impact of the GOP tax  overhaul.


    • Congressional Republicans are finalizing a tax-reform package that will reshape the business environment by lowering the corporate-tax rate and overhauling deductions. 

    • But will the plan's far-reaching changes provide the boost to investment and growth that its backers promise?


    ROBERT J. BARRO | How US Corporate Tax Reform Will Boost Growth

    JASON FURMAN & LAWRENCE H. SUMMERS | Robert Barro's Tax Reform Advocacy: A Response

  3. Murdoch's Last Stand?

    Rupert Murdoch’s sale of 21st Century Fox’s entertainment assets to Disney for $66 billion may mark the end of the media mogul’s career, which will long be remembered for its corrosive effect on democratic discourse on both sides of the Atlantic. 

    From enabling the rise of Donald Trump to hacking the telephone of a murdered British schoolgirl, Murdoch’s media empire has staked its success on stoking populist rage.

  4. Bank of England Leon Neal/Getty Images

    The Dangerous Delusion of Price Stability

    Since the hyperinflation of the 1970s, which central banks were right to combat by whatever means necessary, maintaining positive but low inflation has become a monetary-policy obsession. But, because the world economy has changed dramatically since then, central bankers have started to miss the monetary-policy forest for the trees.

  5. Harvard’s Jeffrey Frankel Measures the GOP’s Tax Plan

    Jeffrey Frankel, a professor at Harvard University’s Kennedy School of Government and a former member of President Bill Clinton’s Council of Economic Advisers, outlines the five criteria he uses to judge the efficacy of tax reform efforts. And in his view, the US Republicans’ most recent offering fails miserably.

  6. A box containing viles of human embryonic Stem Cell cultures Sandy Huffaker/Getty Images

    The Holy Grail of Genetic Engineering

    CRISPR-Cas – a gene-editing technique that is far more precise and efficient than any that has come before it – is poised to change the world. But ensuring that those changes are positive – helping to fight tumors and mosquito-borne illnesses, for example – will require scientists to apply the utmost caution.

  7. The Year Ahead 2018

    The world’s leading thinkers and policymakers examine what’s come apart in the past year, and anticipate what will define the year ahead.

    Order now