二十五年与HIV/AIDS的抗争

自从免疫缺乏综合症(AIDS)被人们认识以来已经过去了二十五个年头。从那时起所获得的知识是激动人心的,而基础研究被转化成拯救生命的治疗方法的步伐也是前所未有的。

在发现了人类免疫缺陷病毒(HIV)是艾滋病的致病原因后,接着有解释了它的致病机理、自然史、流行病学,创立了诊断性血液检验、开发了抗逆转录病毒药物。1996年,对于一类名为蛋白酶抑制剂的首批药物的批准带来一种多药、抗HIV疗程,即高效抗逆转录病毒治疗(HAART)的被采用。这一进展极大地改观了生活的质量,并且增强了HIV感染者对生命的期望。

此外,给感染HIV病毒的孕妇和新生儿服用抗逆转录病毒药物后,在预防母婴传染HIV病毒方面取得了巨大的成功。其结果是,自从这些合成药物被引入以来,单单在美国就已经至少挽救了累计三百万年的生命。现在我们已经有了超过二十四中被认可的抗HIV药物和合成药物,并且还有源源不断的处于研发和临床试验等各种不同阶段的下一代药物。

To continue reading, please log in or enter your email address.

Registration is quick and easy and requires only your email address. If you already have an account with us, please log in. Or subscribe now for unlimited access.

required

Log in

http://prosyn.org/1CgeShm/zh;
  1. An employee works at a chemical fiber weaving company VCG/Getty Images

    China in the Lead?

    For four decades, China has achieved unprecedented economic growth under a centralized, authoritarian political system, far outpacing growth in the Western liberal democracies. So, is Chinese President Xi Jinping right to double down on authoritarianism, and is the “China model” truly a viable rival to Western-style democratic capitalism?

  2. The assembly line at Ford Bill Pugliano/Getty Images

    Whither the Multilateral Trading System?

    The global economy today is dominated by three major players – China, the EU, and the US – with roughly equal trading volumes and limited incentive to fight for the rules-based global trading system. With cooperation unlikely, the world should prepare itself for the erosion of the World Trade Organization.

  3. Donald Trump Saul Loeb/Getty Images

    The Globalization of Our Discontent

    Globalization, which was supposed to benefit developed and developing countries alike, is now reviled almost everywhere, as the political backlash in Europe and the US has shown. The challenge is to minimize the risk that the backlash will intensify, and that starts by understanding – and avoiding – past mistakes.

  4. A general view of the Corn Market in the City of Manchester Christopher Furlong/Getty Images

    A Better British Story

    Despite all of the doom and gloom over the United Kingdom's impending withdrawal from the European Union, key manufacturing indicators are at their highest levels in four years, and the mood for investment may be improving. While parts of the UK are certainly weakening economically, others may finally be overcoming longstanding challenges.

  5. UK supermarket Waring Abbott/Getty Images

    The UK’s Multilateral Trade Future

    With Brexit looming, the UK has no choice but to redesign its future trading relationships. As a major producer of sophisticated components, its long-term trade strategy should focus on gaining deep and unfettered access to integrated cross-border supply chains – and that means adopting a multilateral approach.

  6. The Year Ahead 2018

    The world’s leading thinkers and policymakers examine what’s come apart in the past year, and anticipate what will define the year ahead.

    Order now