Les enfants doivent-ils prendre des antidépresseurs ?

Les 12 derniers mois ont été témoins de changements radicaux et d'une controverse considérable portant sur le mode de traitement de la dépression des enfants et des adolescents. Bien que peu d'antidépresseurs aient reçu une licence pour un usage pédiatrique, les taux de prescription de ces médicaments pour les moins de 18 ans ont augmenté d'environ 60 % au cours de la derničre décennie, plus d'un million d'enfants et d'adolescents recevant des inhibiteurs sélectifs du recaptage de la sérotonine (ISRS).

Toutefois, ŕ l'heure actuelle, les préoccupations relatives ŕ la sécurité et aux effets secondaires de ces médicaments chez les enfants et les adolescents, y compris les taux de suicide élevés, ont éveillé l'attention des organismes de régulation de plusieurs pays. Aprčs avoir examiné tous les essais pédiatriques pertinents, la MHRA (Medinces and Heathcare products Regulatory Agency) du Royaume-Uni a indiqué que les risques l'emportaient sur les avantages pour tous les ISRS (ŕ l'exception de la fluoxetine) et que ces produits ne devaient pas ętre prescrits en tant que nouveau traitement pour les patients de moins de 18 ans souffrant d'une maladie dépressive.

Pour la premičre fois, la MHRA a rendu public un résumé de l'étude sur laquelle se fonde cette décision, incluant les données d'efficacité et de sécurité de tous les essais, qu'elles aient déjŕ été publiées ou non. Cette action s'est avérée importante car environ la moitié des essais n'avaient jamais été publiés dans des journaux lus par les pairs.

To continue reading, please log in or enter your email address.

Registration is quick and easy and requires only your email address. If you already have an account with us, please log in. Or subscribe now for unlimited access.


Log in

  1. Television sets showing a news report on Xi Jinping's speech Anthony Wallace/Getty Images

    Empowering China’s New Miracle Workers

    China’s success in the next five years will depend largely on how well the government manages the tensions underlying its complex agenda. In particular, China’s leaders will need to balance a muscular Communist Party, setting standards and protecting the public interest, with an empowered market, driving the economy into the future.

  2. United States Supreme Court Hisham Ibrahim/Getty Images

    The Sovereignty that Really Matters

    The preference of some countries to isolate themselves within their borders is anachronistic and self-defeating, but it would be a serious mistake for others, fearing contagion, to respond by imposing strict isolation. Even in states that have succumbed to reductionist discourses, much of the population has not.

  3.  The price of Euro and US dollars Daniel Leal Olivas/Getty Images

    Resurrecting Creditor Adjustment

    When the Bretton Woods Agreement was hashed out in 1944, it was agreed that countries with current-account deficits should be able to limit temporarily purchases of goods from countries running surpluses. In the ensuing 73 years, the so-called "scarce-currency clause" has been largely forgotten; but it may be time to bring it back.

  4. Leaders of the Russian Revolution in Red Square Keystone France/Getty Images

    Trump’s Republican Collaborators

    Republican leaders have a choice: they can either continue to collaborate with President Donald Trump, thereby courting disaster, or they can renounce him, finally putting their country’s democracy ahead of loyalty to their party tribe. They are hardly the first politicians to face such a decision.

  5. Angela Merkel, Theresa May and Emmanuel Macron John Thys/Getty Images

    How Money Could Unblock the Brexit Talks

    With talks on the UK's withdrawal from the EU stalled, negotiators should shift to the temporary “transition” Prime Minister Theresa May officially requested last month. Above all, the negotiators should focus immediately on the British budget contributions that will be required to make an orderly transition possible.

  6. Ksenia Sobchak Mladlen Antonov/Getty Images

    Is Vladimir Putin Losing His Grip?

    In recent decades, as President Vladimir Putin has entrenched his authority, Russia has seemed to be moving backward socially and economically. But while the Kremlin knows that it must reverse this trajectory, genuine reform would be incompatible with the kleptocratic character of Putin’s regime.

  7. Right-wing parties hold conference Thomas Lohnes/Getty Images

    Rage Against the Elites

    • With the advantage of hindsight, four recent books bring to bear diverse perspectives on the West’s current populist moment. 
    • Taken together, they help us to understand what that moment is and how it arrived, while reminding us that history is contingent, not inevitable

    Global Bookmark

    Distinguished thinkers review the world’s most important new books on politics, economics, and international affairs.

  8. Treasury Secretary Steven Mnuchin Bill Clark/Getty Images

    Don’t Bank on Bankruptcy for Banks

    As a part of their efforts to roll back the 2010 Dodd-Frank Act, congressional Republicans have approved a measure that would have courts, rather than regulators, oversee megabank bankruptcies. It is now up to the Trump administration to decide if it wants to set the stage for a repeat of the Lehman Brothers collapse in 2008.