Léčba dědičné rakoviny prsu

Ve vyspělých zemích rakovina prsu postihuje asi každou desátou ženu a v mnoha těchto zemích se onemocnění vyskytuje čím dál častěji. Ať už je však důvod (či důvody) nárůstu jeho četnosti jakýkoliv, víme také, že 5% až 10% výskytů rakoviny prsu způsobuje dědičné poškození, které postihuje gen BRCA1 nebo BRCA2.

Nositelkám mutovaného genu BRCA1 nebo BRCA2 hrozí zhruba 80% riziko, že se u nich vyvine rakovina prsu. Mutace těchto genů taktéž vede ke zvýšenému riziku vývinu ovariálních tumorů.

Když byly geny BRCA1 a BRCA2 před více než deseti lety objeveny, vznikly velké naděje na vývoj zcela nových a cílených terapií. Žel bohu, žádné nové způsoby léčby dosud nevznikly. Mnoho žen s vysokou úrovní výskytu mutovaných genů BRCA1 nebo BRCA2 proto čelí tragické volbě, zda si nechat chirurgicky odejmout ňadra a vaječníky, aby se preventivně bránily rakovině.

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