Die Schwierigkeit der Vorhersage von Alzheimer

LONDON – Die Alzheimer-Krankheit ist die bei weitem häufigste Ursache für Demenz und international eine der meistgefürchteten Krankheiten. Bis 2050 werden weltweit 135 Millionen Menschen an Alzheimer leiden – eine Verdreifachung des heutigen Wertes – wobei drei Viertel aller Fälle in Ländern niedrigen und mittleren Einkommens auftreten werden. Die Vorhersage des Ausbruchs von Alzheimer - von Prävention oder Heilung ganz zu schweigen - bleibt eine immense Herausforderung.

Die Alzheimer-Krankheit wurde vor mehr als einem Jahrhundert aufgrund von Autopsie-Ergebnissen entdeckt, die charakteristische Hirnläsionen zeigten -  so genannte „amyloide Plaques“. Bei lebenden Personen ist die Krankheit schwieriger zu diagnostizieren. Ärzte sind auf die Beobachtung von Gedächtnisverlust und anderen geistigen Defiziten (wie logisches Denken oder Sprachverständnis) angewiesen – Zeichen, dass sich im Gehirn bereits Plaques abgelagert hat. Ein Heilmittel müsste allerdings verabreicht werden, bevor sich Plaques bildet und  bereits Jahre bevor die Symptome der Demenz auftreten.

Man könnte Alzheimer leichter vorhersagen, wenn Wissenschaftler über Zeit und Ressourcen verfügten, viele Jahre lang weitreichende Längsschnittstudien durchzuführen. Im Rahmen derartiger Studien würde man idealerweise an tausenden Personen jüngeren und mittleren Alters Blutuntersuchungen, bildgebende Verfahren, Gedächtnistests und medizinische Untersuchungen durchführen sowie die Studienteilnehmer detaillierte Fragebögen zur Lebensqualität beantworten lassen. Man würde die Probanden jahrzehntelang begleiten, um herauszufinden, ob sie die Krankheit entwickeln und welche Tests vor der Alzheimer-Diagnose positiv verliefen.

To continue reading, please log in or enter your email address.

Registration is quick and easy and requires only your email address. If you already have an account with us, please log in. Or subscribe now for unlimited access.


Log in

  1. Television sets showing a news report on Xi Jinping's speech Anthony Wallace/Getty Images

    Empowering China’s New Miracle Workers

    China’s success in the next five years will depend largely on how well the government manages the tensions underlying its complex agenda. In particular, China’s leaders will need to balance a muscular Communist Party, setting standards and protecting the public interest, with an empowered market, driving the economy into the future.

  2. United States Supreme Court Hisham Ibrahim/Getty Images

    The Sovereignty that Really Matters

    The preference of some countries to isolate themselves within their borders is anachronistic and self-defeating, but it would be a serious mistake for others, fearing contagion, to respond by imposing strict isolation. Even in states that have succumbed to reductionist discourses, much of the population has not.

  3.  The price of Euro and US dollars Daniel Leal Olivas/Getty Images

    Resurrecting Creditor Adjustment

    When the Bretton Woods Agreement was hashed out in 1944, it was agreed that countries with current-account deficits should be able to limit temporarily purchases of goods from countries running surpluses. In the ensuing 73 years, the so-called "scarce-currency clause" has been largely forgotten; but it may be time to bring it back.

  4. Leaders of the Russian Revolution in Red Square Keystone France/Getty Images

    Trump’s Republican Collaborators

    Republican leaders have a choice: they can either continue to collaborate with President Donald Trump, thereby courting disaster, or they can renounce him, finally putting their country’s democracy ahead of loyalty to their party tribe. They are hardly the first politicians to face such a decision.

  5. Angela Merkel, Theresa May and Emmanuel Macron John Thys/Getty Images

    How Money Could Unblock the Brexit Talks

    With talks on the UK's withdrawal from the EU stalled, negotiators should shift to the temporary “transition” Prime Minister Theresa May officially requested last month. Above all, the negotiators should focus immediately on the British budget contributions that will be required to make an orderly transition possible.

  6. Ksenia Sobchak Mladlen Antonov/Getty Images

    Is Vladimir Putin Losing His Grip?

    In recent decades, as President Vladimir Putin has entrenched his authority, Russia has seemed to be moving backward socially and economically. But while the Kremlin knows that it must reverse this trajectory, genuine reform would be incompatible with the kleptocratic character of Putin’s regime.

  7. Right-wing parties hold conference Thomas Lohnes/Getty Images

    Rage Against the Elites

    • With the advantage of hindsight, four recent books bring to bear diverse perspectives on the West’s current populist moment. 
    • Taken together, they help us to understand what that moment is and how it arrived, while reminding us that history is contingent, not inevitable

    Global Bookmark

    Distinguished thinkers review the world’s most important new books on politics, economics, and international affairs.

  8. Treasury Secretary Steven Mnuchin Bill Clark/Getty Images

    Don’t Bank on Bankruptcy for Banks

    As a part of their efforts to roll back the 2010 Dodd-Frank Act, congressional Republicans have approved a measure that would have courts, rather than regulators, oversee megabank bankruptcies. It is now up to the Trump administration to decide if it wants to set the stage for a repeat of the Lehman Brothers collapse in 2008.